Rush Peptide Synthesis in Action

Introducing LifeTein's faster microwave peptide synthesis technology!

LifeTein's new platform is designed for maximized speed and efficiency. Unparalleled peptide quality, greater flexibility, and improved reliability make LifeTein the vendor of choice for all your peptide synthesis needs.

Remarkably Fast:

• Rush synthesis service in 3-5 Days
• Difficult peptides such as beta-Amyloid in hours rather than days
• 4-minute cycle time

LifeTein provides the fastest turnaround time and most reliable quality in the industry. Peptides are made in New Jersey, USA. Projects move from conception to bench in only 3–5 days so you can deal with your research deadlines.

Accelerate Your Research: Move your peptides to the top of the queue at every step in the peptide synthesis process. LifeTein peptides are synthesized and shipped 40% faster than the industry standard. Actual shipping times are based on the individual peptide and protein characteristics.

Made in the USA 🇺🇸: Rest assured that your rush peptide orders are made in New Jersey, 100% accurate and compliant with all intellectual property laws.

LifeTein’s Synthetic Scorpion Toxin Peptides Helped Scientists Unravel Chronic Pain Mechanisms

LifeTein’s synthetic Wasabi Receptor Toxin, Wasabi Receptor Toxin Mutants, Biotinylated Wasabi Receptor Toxin, and AlexaFluor-488 conjugated Wasabi Receptor Toxin and Mutants helped scientists unravel chronic pain mechanisms.

Researchers at the University of California, San Francisco (UCSF) have identified a scorpion toxin that targets the “wasabi receptor”. The wasabi receptor is an ion channel protein that is responsible for the sinus-clearing or eye-stinging pain experienced when eating wasabi or chopping onions.

It was found that the scorpion toxin, a peptide as the wasabi receptor toxin, or WaTx, activates the wasabi receptor TRPA1 and triggers this pain response to irritants. The WaTx peptide is a novel cell-penetrating peptide and can directly pass through the plasma membrane, without needing to traverse through channel proteins.

The WaTx peptide could be used to study chronic pain and inflammation and may lead to the development of novel non-opioid pain therapies. WaTx produces pain and pain hypersensitivity, but not neurogenic inflammation.

https://www.lifetein.com/blog/lifeteins-synthetic-scorpion-toxin-peptides-helped-scientists-unravel-chronic-pain-mechanisms/

Reference: Lin King, J. V., Emrick, J. J., Kelly, M. J. S., Herzig, V., King, G. F., Medzihradszky, K. F., & Julius, D. (2019). A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. Cell. doi:10.1016/j.cell.2019.07.014

A click chemistry was reported about the formation of azides from primary amines

A click chemistry was reported about the formation of azides from primary amines. This powerful tool enables the reaction of just one equivalent of a simple diazotizing species, and fluorosulfuryl azide (FSO2N3), for the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This method greatly expands the number of accessible azides and 1,2,3-triazoles because the primary amine is one of the most abundant functional groups in small compounds, proteins and antibodies.

The method opens the door for numerous applications in drug screening and discovery. The cell penetration peptides can be easily introduced to conjugate with any azide containing drugs, compounds, antibodies, or proteins.

The cell penetration peptides (CPPs) are capable of delivering biologically active cargo to the cell interior. The desired therapeutic cargo could be attached to a CPP using the copper free click chemistry and then delivered to an intracellular target, thereby overcoming the entry restrictions set by the plasma membrane.

How to form the fibrillary structure using beta-amyloid peptides?

Aβ-(1–42) was dissolved to 1 mM in 100% hexafluoroisopropanol, hexafluoroisopropanol was removed under vacuum, and the peptide was stored at −20 °C. For the aggregation protocols, the peptide was first resuspended in dry Me2SO (DMSO) to 5 mM. For oligomeric conditions, F-12 (without phenol red) culture media was added to bring the peptide to a final concentration of 100 μM, and the peptide was incubated at 4 °C for 24 h. For fibrillar conditions, 10 mM HCl was added to bring the peptide to a final concentration of 100 μM, and the peptide was incubated for 24 h at 37 °C. ADDLS, amyloid derived diffusible ligands.

Aducanumab is a human monoclonal antibody that has been studied for the treatment of Alzheimer’s disease.

The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza

https://www.lifetein.com/blog/the-nobel-prize-in-physiology-or-medicine-2019-was-awarded-jointly-to-william-g-kaelin-jr-sir-peter-j-ratcliffe-and-gregg-l-semenza/

The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza. One of the key peptides was made by LifeTein: HIF1a-P564: DLDLEMLAPYIPMDDDFQLR.

Winter Promotion: Keep warm with a Land's End fleece

Winter Promotion: Keep warm with a Land's End fleece ($59 Value, US Customer Only)

From Dec. 8, 2014 to Dec. 31, 2014 get a free fleece ($59 Value) for any purchase of $500 or more*.

See offer details. *View terms and conditions. *Limit one offer per customer. No combining offers. Not applicable to prior purchases. Limited to stock on hand. Void where prohibited.

http://www.lifetein.com/free-gift-promotions.html

25% Off peptide synthesis for new customers plus free shipping