Biotin labeled peptides were synthesized by LifeTein and conjugated with nanoparticles. A 6-amino-hexanoic linker was added between biotin and peptide to form a flexible space. It was found that a peptide designed for tumour-homing with a carboxy-terminal, basic sequence motif can act as cell penetration peptide to enter tumour tissue. This is a breakthrough for drug delivery into tumours. In addition, this neuropilins mediated endocytosis is distinct from known endocytic pathways. The nutrient regulation of the pathway is a new finding to use of the C-terminal, basic sequence motif pathway in drug delivery.
http://www.lifetein.com/Quality-Peptides-For-Publications.html
LifeTein, located in Somerset, New Jersey, was founded in 2008 with a simple vision: understanding life one protein at a time. This philosophy has formed the foundation of every peptide, antibody, protein, antibody, and chemical project that we have completed for our customers in the academic, biotechnology, agricultural, government institutions and pharmaceutical fields.
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